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Individual behavioral profiling as a translational approach to assess treatment efficacy in an animal model of PTSD
At present, the research of psychiatric pharmacological treatments in animal models mainly utilizes the comparison of group averages in order to investigate treatment efficacy. Clinically, these treatments usually result in partial success rates. Specifically, the first line pharmacological treatments in […]
Stress-related disorders, individual differences, and personalized medicine
The term “stress” holds a negative connotation to it. However, in both humans and animals, a surprisingly high level of resilience is found, indicating that resilience is the rule and stress-related pathology the exception. Indeed, studies indicate that stress has […]
Understanding behavioral meta-plasticity:
Meta-plasticity is a term describing the induction of plasticity in a system, which then alters the probability of inducing plasticity later on (Abraham & Bear, 1996). We have expanded the notion of this term, to include also Behavioral Meta-plasticity, to […]
The Amygdala, “Emotional Tagging” and emotional modulation of memory formation:
At any given moment our brain is bombarded with stimuli from our external and internal environment. Within this flood of information, effective memory systems, such as the hippocampus, are required to be able to identify the more relevant aspects, in […]