Joyeeta Dutta Hazra
“Role of GABAergic inhibitory synapses at specific subcellular domains of Principal Neurons in Amygdala regulating Fear learning and Memory”
Fear is a natural, evolutionarily developed response to environmental threats. GABAergic synapse mediated feedback and feedforward inputs determine how the excitatory inputs to the principal cells involved in fear learning will be processed in the amygdala. In this current project our goal is to examine the role of specific subcellular GABAergic synapses of principal neurons in basolateral amygdala neural circuits using Fear conditioning which is a frequently used paradigm for studying the neurobiology of various anxiety disorders.
My current projects aims to determine a personalized set of biomarker comprising epigenetic, endocrine and immunological markers to predict susceptibility to PTSD and individual response towards its treatment. The approach employed is to behaviorally profile along with blood and brain tissue analysis of rats, whose degree of response to stress and treatment varies individually. Determining set of biomarkers for varied stresses experienced at different stages of life together with different kinds of treatments in an individual specific manner brings us closer to the development of personalized medicine.